Here, we designed monomer and multimer protein constructs, which comprised the globular interaction recognition parts of mouse C1q (globular part of C1q ) as single-chain molecules (sc-gC1q proteins) lacking the collagen-like effector region. However, the molecular mechanism of C1q-associated synapse phagocytosis is still unclear. In addition, C1q was recently described in the central nervous system as having a role in synapse elimination both in the healthy brain and in neurodegenerative diseases. Glycobiology and Extracellular MatricesĬomplement component C1q is a protein complex of the innate immune system with well-characterized binding partners that constitutes part of the classical complement pathway.
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